Home > About > Faculty Profiles > Yuriy Markushin, PhD

Yuriy Markushin, PhD

Associate Professor
Delaware State University
Division of Physics, Engineering, Mathematics and Computer Sciences
& Optical Science Center for Applied Research (OSCAR)
ymarkushin [at] desu.edu


Materials characterization; Attenuated total reflectance-Fourier transform infrared spectroscopy; Raman spectroscopy; Laser induced breakdown spectroscopy; Fluorescence; Microscopy; Machine learning techniques; Uptake and distribution of nanoparticles and carbon nanotubes in plants; Biomedical applications; Immunoassay & lateral flow assays development; Antibody-antigen interaction; Self-organized polymeric nanostructures; Organic material identification and elemental analysis of the rocks and other samples in the field and in the laboratory; Airborne thermography and photography based identification of suitable rocks as a potential source for the biosignatures of life.


  1. A. Safi, J.E. Landis, H.G. Adler, H. Khadem, K.E. Eseller, Y. Markushin, S. Honarparvaran, A. De Giacomo, N. Melikechi. (2024) Enhancing biomarker detection sensitivity through tag-laser induced breakdown spectroscopy with NELIBS. Talanta. 271, 125723.
  2. Y. Markushin. Enhancement compositions and uses thereof. Patent Application: 63/320,758, 2022, PCT/US2023/015474, 2023.
  3. F. Candan, Y. Markushin, G. Ozbay. (2022) Uptake and Presence Evaluation of Nanoparticles in Cicer arietinum L. by Infrared Spectroscopy and Machine Learning Techniques. Plants (Basel). 11, 1569.
  4. N. Melikechi, Y. Markushin. (2022) Tag-laser-induced breakdown spectroscopy with Si, Ti, and Fe micro-particles and analysis of leptin in a phosphate buffer solution, Spectrochimica Acta Part B: Atomic Spectroscopy, 188, 106357.
  5. N. Melikechi, Y. Markushin, D. Connolly, J. Lasue , E. Ewusi-Annan, S. Makrogiannis. (2016) Age-specific discrimination of blood plasma samples of healthy and ovarian cancer prone mice using laser-induced breakdown spectroscopy. Spectrochimica Acta Part B, 123, 33–41.
  6. S. C. Jantzi, V. Motto-Ros, F. Trichard, Y. Markushin, N. Melikechi, A. De Giacomo. (2016) Sample treatment and preparation for laser-induced breakdown spectroscopy. Spectrochimica Acta Part B, 115, 52–63.
  7. Y. Markushin, P. Sivakumar, D. Connolly, N. Melikechi. (2015) Tag-femtosecond laser-induced breakdown spectroscopy for the sensitive detection of cancer antigen 125 in blood plasma. Anal. Bioanal. Chem., 407, 1849-1855.
  8. D. Pokrajac, A. Lazarevic, V. Kecman, A. Marcano, Y.Markushin, T. Vance, N. Reljin, S. McDaniel, N. Melikechi. (2014) Automatic classification of laser-induced breakdown spectroscopy (LIBS) data of protein biomarker solutions. Appl Spectrosc. 68, 1067-75.
  9. Y. Markushin and N. Melikechi (2012). Sensitive Detection of Epithelial Ovarian Cancer Biomarkers Using Tag-Laser Induced Breakdown Spectroscopy, in: Ovarian Cancer - Basic Science Perspective, Edited by S. A. Farghaly, InTech, Chapter 9, 153 – 170.
  10. A. Marcano O., D. Pokrajac, A. Lazarevic, M. Smith, Y. Markushin, and N. Melikechi. (2011) Statistical Analysis for Automatic Identification of Ovarian Cancer Protein-Biomarkers Based on Fast Fourier Transform Infrared Spectroscopy, in Fourier Transforms - New Analytical Approaches and FTIR Strategies. London, United Kingdom: IntechOpen, 2011. Available: https://www.intechopen.com/chapters/14623 doi: 10.5772/16008
  11. T. Vance, D. Pokrajac, A. Lazarevic, A. Marcano, Y. Markushin, S. McDaniel, and N. Melikechi (2010). Classification of LIBS Protein Spectra Using Multilayer Perceptrons. Transactions on Mass-Data Analysis of Images and Signals, 2, 96 -111.
  12. Y. Markushin, A. Marcano,  S. Rock, N. Melikechi (2010) Determination of protein hydrogen composition by laser-induced breakdown spectroscopy. J. Anal. At. Spectrom. 25: 148-149.


  1. MUREP Space Technology Artemis Research (M-STAR): “Constraining Exospheric Water Using Mid-IR Sensing and LIBS for Lunar Rover Missions”, Role: co-PI, Amount: $899,000; Duration: 09/26/2023 to 09/25/2026.
  2. Congressionally Directed Spending Request/NASA: “Space Education Excellence for Delaware (SEED)” Role: co-I; Amount: $900,000; Duration: 07/01/2023  to 06/30/2025.


  1. General Physics  
  2. Statistical mechanics 
  3. Principle of lasers and optical devices
  4. Modern laser spectroscopic methods
  5. Optical Electronics
  6. Biophotonics I: Principles of Luminescence
  7. Foundations of Bioengineering
  8. Biosensors/Bioinstrumentation
  9. Introduction to Micro-electromechanical systems (MEMS)


“Mission to Mars” weekly class was developed and added to the curriculum of the Dover Middle School Campus (Dover, DE) for the Spring Semester 2024. Participation: 10 middle school students with 2 PhD students, a faculty and a teacher involving in the teaching,